Mickaël CANOUIL

Curriculum Vitæ

Experience

Jan. 2016 --
Present

Head of the Biostatistic Team

Laboratory of Integrated Genomics and Metabolic Diseases Modeling - UMR 8199 (CNRS / University of Lille 2 / Pasteur Institute Lille), Lille, France

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Headed by Pr. P. Froguel
Sept. 2012 --
Dec. 2015

Biostatistician

Laboratory of Integrated Genomics and Metabolic Diseases Modeling - UMR 8199 (CNRS / University of Lille 2 / Pasteur Institute Lille), Lille, France

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments

Headed by Pr. P. Froguel
Nov. 2011 --
Dec. 2011

Biostatistician

The French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR) - UMRESTTE - UMR T9405, Bron, France

Activities: Analysis of a mobility and accident study in secondary-school pupils

Supervised by Dr. M. Haddak
Jan. 2011 --
Jun. 2011

Biostatistician (Internship)

Hospices Civiles de Lyon - Biostatistics Unit - UMR CNRS 5558, Lyon, France

Activities: Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data

Supervised by Pr. R. Ecochard et Dr. C. Genolini
Mar. 2010 --
Jun. 2010

Biostatistician (Internship)

Laboratory of Biometry and Evolutionary Biology (LBBE) - UMR CNRS 5558, Lyon, France

Activities: Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward

Supervised by Dr. C. Kribs-Zaleta

Education

Oct. 2014 --
Sept. 2017

Doctor of Philosophy (Ph.D.) in BioStatistics

University of Lille 2, Lille, France

“ Development and Application of Statistical Methods for Multi-Omics Studies in Type 2 Diabetes: Beyond the Genome-Wide Association Studies Era ”

Supervised by Pr. P. Froguel and Dr. G. Rocheleau
Sept. 2009 --
Jul. 2011

Master's Degree in Biostatistics, Bioinformatics and Genomics

Specialised in Biostatistics

University Claude Bernard Lyon 1, Lyon, France

Sept. 2006 --
Jul. 2009

Bachelor's Degree in Biology

Specialised in Biostatistics

University Claude Bernard Lyon 1, Lyon, France

Computer Skills

Basic
C, SQL
Intermediate
Julia, Lua, Perl, Python, SAS
Advanced
R, LATEX, HTML, css, Markdown

Languages

French
Native
English
Fluent / Full Professional Proficiency
Spanish
Elementary Proficiency

Publications

Variable Clustering in High-Dimensional Linear Regression: The R Package clere

Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil

The R Journal (2016)

Hepatic DPP4 DNA-Methylation Associates With Fatty Liver

Christian Baumeier*, Sophie Saussenthaler*, Anne Kammel, Markus Jähnert, Luisa Schlüter, Deike Hesse, Mickaël Canouil, Stephane Lobbens, Robert Caiazzo, Violeta Raverdy, François Pattou, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann and Robert W. Schwenk
*These authors contributed equally to the present study.

Diabetes (2016)

Decreased STARD10 Expression is Associated with Defective Insulin Secretion in Humans And Mice

Gaelle R. Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle Gaulton, Martijn van de Bunt, Afshan Siddiq, Mario Falchi, Matthias Thurner, Mickaël Canouil, Francois Pattou, Isabelle Leclerc, Timothy J. Pullen, Matthew C. Cane, Priyanka Prabhala, William Greenwald, Anke Schulte, Piero Marchetti, Mark Ibberson, Patrick MacDonald, Jocelyn E. Manning Fox, Anna L. Gloyn, Philippe Froguel, Michele Solimena, Mark I. McCarthy and Guy A. Rutter

The American Journal of Human Genetics (2017)

Relationship Between Salivary/Pancreatic Amylase and Body Mass Index: A Systems Biology Approach

Amélie Bonnefond*, Loïc Yengo*, Aurélie Dechaume, Mickaël Canouil, Maxime Castelain, Estelle Roger, Frédéric Allegaert, Robert Caiazzo, Violeta Raverdy, Marie Pigeyre, Abdelilah Arredouani, Jean-Michel Borys, Claire Lévy-Marchal, Jacques Weill, Ronan Roussel, Beverley Balkau, Michel Marre, François Pattou, Thierry Brousseau and Philippe Froguel
*These authors contributed equally to the present study. These authors contributed equally to the present study.

BMC Medicine (2017)

Expression and Functional Assessment of Candidate Type 2 Diabetes Susceptibility Genes Identify Four New Genes Contributing to Human Insulin Secretion

Fatou K Ndiaye*, Ana Ortalli*, Mickaël Canouil*, Marlène Huyvaert, Clara Salazar-Cardozo, Cécile Lecoeur, Marie Verbanck, Valérie Pawlowski, Raphaël Boutry, Emmanuelle Durand, Iandry Rabearivelo, Olivier Sand, Lorella Marselli, Julie Kerr-Conte, Vikash Chandra, Raphaël Scharfmann, Odile Poulain-Godefroy, Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel and Amélie Bonnefond
*These authors contributed equally to the present study. These authors are co-senior authors on this work.

Molecular Metabolism (2017)

Low-Dose Exposure to Bisphenols A, F and S of Human Primary Adipocyte Impacts Coding and Non-Coding RNA Profiles

Marie Verbanck*, Mickaël Canouil*, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel, Odile Poulain-Godefroy
*These authors contributed equally to this work. These authors are co-senior authors on this work.

PLoS ONE (2017)

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Yun J. Sung*, Thomas W. Winkler*, Lisa de las Fuentes*, Amy R. Bentley*, Michael R. Brown*, Aldi T. Kraja*, Karen Schwander*, Ioanna Ntalla*, Xiuqing Guo, Nora Franceschini, Yingchang Lu, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Tuomas O. Kilpeläinen, Melissa A. Richard, Raymond Noordam, Stella Aslibekyan, Hugues Aschard, Traci M. Bartz, Rajkumar Dorajoo, Yongmei Liu, Alisa K. Manning, Tuomo Rankinen, Albert Vernon Smith, Salman M. Tajuddin, Bamidele O. Tayo, Helen R. Warren, Wei Zhao, Yanhua Zhou, Nana Matoba, Tamar Sofer, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Ilaria Gandin, Chuan Gao, Franco Giulianini, Anuj Goel, Sarah E. Harris, Fernando Pires Hartwig, Andrea R.V.R. Horimoto, Fang-Chi Hsu, Anne U. Jackson, Mika Kähönen, Anuradhani Kasturiratne, Brigitte Kühnel, Karin Leander, Wen-Jane Lee, Keng-Hung Lin, Jian ’an Luan, Colin A. McKenzie, He Meian, Christopher P. Nelson, Rainer Rauramaa, Nicole Schupf, Robert A. Scott, Wayne H.H. Sheu, Alena Stančáková, Fumihiko Takeuchi, Peter J. van der Most, Tibor V. Varga, Heming Wang, Yajuan Wang, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Tamuno Alfred, Najaf Amin, Dan Arking, Tin Aung, R. Graham Barr, Lawrence F. Bielak, Eric Boerwinkle, Erwin P. Bottinger, Peter S. Braund, Jennifer A. Brody, Ulrich Broeckel, Claudia P. Cabrera, Brian Cade, Yu Caizheng, Archie Campbell, Mickaël Canouil, Aravinda Chakravarti, The CHARGE Neurology Working Group, Ganesh Chauhan, Kaare Christensen, Massimiliano Cocca, The COGENT-Kidney Consortium, Francis S. Collins, John M. Connell, Renée de Mutsert, H. Janaka de Silva, Stephanie Debette, Marcus Dörr, Qing Duan, Charles B. Eaton, Georg Ehret, Evangelos Evangelou, Jessica D. Faul, Virginia A. Fisher, Nita G. Forouhi, Oscar H. Franco, Yechiel Friedlander, He Gao, The GIANT Consortium, Bruna Gigante, Misa Graff, C. Charles Gu, Dongfeng Gu, Preeti Gupta, Saskia P. Hagenaars, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, Albert Hofman, Barbara V. Howard, Steven Hunt, Marguerite R. Irvin, Yucheng Jia, Roby Joehanes, Anne E. Justice, Tomohiro Katsuya, Joel Kaufman, Nicola D. Kerrison, Chiea Chuen Khor, Woon-Puay Koh, Heikki A. Koistinen, Pirjo Komulainen, Charles Kooperberg, Jose E. Krieger, Michiaki Kubo, Johanna Kuusisto, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Benjamin Lehne, Cora E. Lewis, Yize Li, Lifelines Cohort Study, Sing Hui Lim, Shiow Lin, Ching-Ti Liu, Jianjun Liu, Jingmin Liu, Kiang Liu, Yeheng Liu, Marie Loh, Kurt K. Lohman, Jirong Long, Tin Louie, Reedik Mägi, Anubha Mahajan, Thomas Meitinger, Andres Metspalu, Lili Milani, Yukihide Momozawa, Andrew P. Morris, Thomas H. Mosley Jr., Peter Munson, Alison D. Murray, Mike A. Nalls, Ubaydah Nasri, Jill M. Norris, Kari North, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R. Palmas, Nicholette D. Palmer, James S. Pankow, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Ozren Polasek, Olli T. Raitakari, Frida Renström, Treva K. Rice, Paul M. Ridker, Antonietta Robino, Jennifer G. Robinson, Lynda M. Rose, Igor Rudan, Charumathi Sabanayagam, Babatunde L. Salako, Kevin Sandow, Carsten O. Schmidt, Pamela J. Schreiner, William R. Scott, Sudha Seshadri, Peter Sever, Colleen M. Sitlani, Jennifer A. Smith, Harold Snieder, John M. Starr, Konstantin Strauch, Hua Tang, Kent D. Taylor, Yik Ying Teo, Yih Chung Tham, André G. Uitterlinden, Melanie Waldenberger, Lihua Wang, Ya X. Wang, Wen Bin Wei, Christine Williams, Gregory Wilson, Mary K. Wojczynski, Jie Yao, Jian-Min Yuan, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, John C. Chambers, Yii-Der Ida Chen, Ulf de Faire, Ian J. Deary, Tõnu Esko, Martin Farrall, Terrence Forrester, Paul W. Franks, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo Lessa Horta, Yi-Jen Hung, Jost B. Jonas, Norihiro Kato, Jaspal S. Kooner, Markku Laakso, Terho Lehtimäki, Kae-Woei Liang, Patrik K.E. Magnusson, Anne B. Newman, Albertine J. Oldehinkel, Alexandre C. Pereira, Susan Redline, Rainer Rettig, Nilesh J. Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E. Wagenknecht, Nicholas J. Wareham, Hugh Watkins, David R. Weir, Ananda R. Wickremasinghe, Tangchun Wu, Wei Zheng, Yoichiro Kamatani, Cathy C. Laurie, Claude Bouchard, Richard S. Cooper, Michele K. Evans, Vilmundur Gudnason, Sharon L.R. Kardia, Stephen B. Kritchevsky, Daniel Levy, Jeff R. O’Connell, Bruce M. Psaty, Rob M. van Dam, Mario Sims, Donna K. Arnett, Dennis O. Mook-Kanamori, Tanika N. Kelly, Ervin R. Fox, Caroline Hayward, Myriam Fornage, Charles N. Rotimi, Michael A. Province, Cornelia M. van Duijn, E. Shyong Tai, Tien Yin Wong, Ruth J.F. Loos, Alex P. Reiner, Jerome I. Rotter, Xiaofeng Zhu, Laura J. Bierut, W. James Gauderman, Mark J. Caulfield, Paul Elliott, Kenneth Rice, Patricia B. Munroe, Alanna C. Morrison, L. Adrienne Cupples, Dabeeru C. Rao, Daniel I. Chasman
*These authors contributed equally to this work. These authors contributed equally to this work.

The American Journal of Human Genetics (2018)

Refining the Accuracy of Validated Target Identification Through Coding Variant Fine-mapping in Type 2 Diabetes

Anubha Mahajan*, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, Audrey Y. Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, N. William Rayner, Xiuqing Guo, Yingchang Lu, Man Li, Richard A. Jensen, Yao Hu, Shaofeng Huo, Kurt K. Lohman, Weihua Zhang, James P. Cook, Bram Peter Prins, Jason Flannick, Niels Grarup, Vassily Vladimirovich Trubetskoy, Jasmina Kravic, Young Jin Kim, Denis V. Rybin, Hanieh Yaghootkar, Martina Müller-Nurasyid, Karina Meidtner, Ruifang Li-Gao, Tibor V. Varga, Jonathan Marten, Jin Li, Albert Vernon Smith, Ping An, Symen Ligthart, Stefan Gustafsson, Giovanni Malerba, Ayse Demirkan, Juan Fernandez Tajes, Valgerdur Steinthorsdottir, Matthias Wuttke, Cécile Lecoeur, Michael Preuss, Lawrence F. Bielak, Marielisa Graff, Heather M. Highland, Anne E. Justice, Dajiang J. Liu, Eirini Marouli, Gina Marie Peloso, Helen R. Warren, ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Saima Afaq, Shoaib Afzal, Emma Ahlqvist, Peter Almgren, Najaf Amin, Lia B. Bang, Alain G. Bertoni, Cristina Bombieri, Jette Bork-Jensen, Ivan Brandslund, Jennifer A. Brody, Noël P. Burtt, Mickaël Canouil, Yii-Der Ida Chen, Yoon Shin Cho, Cramer Christensen, Sophie V. Eastwood, Kai-Uwe Eckardt, Krista Fischer, Giovanni Gambaro, Vilmantas Giedraitis, Megan L. Grove, Hugoline G. de Haan, Sophie Hackinger, Yang Hai, Sohee Han, Anne Tybjærg-Hansen, Marie-France Hivert, Bo Isomaa, Susanne Jäger, Marit E. Jørgensen, Torben Jørgensen, Annemari Käräjämäki, Bong-Jo Kim, Sung Soo Kim, Heikki A. Koistinen, Peter Kovacs, Jennifer Kriebel, Florian Kronenberg, Kristi Läll, Leslie A. Lange, Jung-Jin Lee, Benjamin Lehne, Huaixing Li, Keng-Hung Lin, Allan Linneberg, Ching-Ti Liu, Jun Liu, Marie Loh, Reedik Mägi, Vasiliki Mamakou, Roberta McKean-Cowdin, Girish Nadkarni, Matt Neville, Sune F. Nielsen, Ioanna Ntalla, Patricia A. Peyser, Wolfgang Rathmann, Kenneth Rice, Stephen S. Rich, Line Rode, Olov Rolandsson, Sebastian Schönherr, Elizabeth Selvin, Kerrin S. Small, Alena Stančáková, Praveen Surendran, Kent D. Taylor, Tanya M. Teslovich, Barbara Thorand, Gudmar Thorleifsson, Adrienne Tin, Anke Tönjes, Anette Varbo, Daniel R. Witte, Andrew R. Wood, Pranav Yajnik, Jie Yao, Loïc Yengo, Robin Young, Philippe Amouyel, Heiner Boeing, Eric Boerwinkle, Erwin P. Bottinger, Rajiv Chowdhury, Francis S. Collins, George Dedoussis, Abbas Dehghan, Panos Deloukas, Marco M. Ferrario, Jean Ferrières, Jose C. Florez, Philippe Frossard, Vilmundur Gudnason, Tamara B. Harris, Susan R. Heckbert, Joanna M. M. Howson, Martin Ingelsson, Sekar Kathiresan, Frank Kee, Johanna Kuusisto, Claudia Langenberg, Lenore J. Launer, Cecilia M. Lindgren, Satu Männistö, Thomas Meitinger, Olle Melander, Karen L. Mohlke, Marie Moitry, Andrew D. Morris, Alison D. Murray, Renée de Mutsert, Marju Orho-Melander, Katharine R. Owen, Markus Perola, Annette Peters, Michael A. Province, Asif Rasheed, Paul M. Ridker, Fernando Rivadineira, Frits R. Rosendaal, Anders H. Rosengren, Veikko Salomaa, Wayne H.-H. Sheu, Rob Sladek, Blair H. Smith, Konstantin Strauch, André G. Uitterlinden, Rohit Varma, Cristen J. Willer, Matthias Blüher, Adam S. Butterworth, John Campbell Chambers, Daniel I. Chasman, John Danesh, Cornelia van Duijn, Josée Dupuis, Oscar H. Franco, Paul W. Franks, Philippe Froguel, Harald Grallert, Leif Groop, Bok-Ghee Han, Torben Hansen, Andrew T. Hattersley, Caroline Hayward, Erik Ingelsson, Sharon L. R. Kardia, Fredrik Karpe, Jaspal Singh Kooner, Anna Köttgen, Kari Kuulasmaa, Markku Laakso, Xu Lin, Lars Lind, Yongmei Liu, Ruth J. F. Loos, Jonathan Marchini, Andres Metspalu, Dennis Mook-Kanamori, Børge G. Nordestgaard, Colin N. A. Palmer, James S. Pankow, Oluf Pedersen, Bruce M. Psaty, Rainer Rauramaa, Naveed Sattar, Matthias B. Schulze, Nicole Soranzo, Timothy D. Spector, Kari Stefansson, Michael Stumvoll, Unnur Thorsteinsdottir, Tiinamaija Tuomi, Jaakko Tuomilehto, Nicholas J. Wareham, James G. Wilson, Eleftheria Zeggini, Robert A. Scott, Inês Barroso, Timothy M. Frayling, Mark O. Goodarzi, James B. Meigs, Michael Boehnke, Danish Saleheen, Andrew P. Morris, Jerome I. Rotter and Mark I. McCarthy
*These authors contributed equally to this work. These authors contributed equally to this work.

Nature (2018)

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes

Amar Abderrahmani*, Loïc Yengo*, Robert Caiazzo*, Mickaël Canouil*, Stéphane Cauchi, Violeta Raverdy, Valérie Plaisance, Valérie Pawlowski, Stéphane Lobbens, Julie Maillet, Laure Rolland, Raphael Boutry, Gurvan Queniat, Maxime Kwapich, Mathie Tenenbaum, Julien Bricambert, Sophie Saussenthaler, Elodie Anthony, Pooja Jha, Julien Derop, Olivier Sand, Iandry Rabearivelo, Audrey Leloire, Marie Pigeyre, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Tasnim Dayeh, Guillaume Lassailly, Philippe Mathurin, Bart Staels, Johan Auwerx, Annette Schürmann, Catherine Postic, Clemens Schafmayer, Jochen Hampe, Amélie Bonnefond, François Pattou and Philippe Froguel
*These authors contributed equally to this work. These authors contributed equally to this work.

Diabetes (2018)

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Mary F. Feitosa*, Aldi T. Kraja*, Daniel I. Chasman*, Yun J. Sung*, Thomas W. Winkler*, Ioanna Ntalla*, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Amy R. Bentley, Michael R. Brown, Karen Schwander, Melissa A. Richard, Raymond Noordam, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Rajkumar Dorajoo, Virginia Fisher, Fernando P. Hartwig, Andrea R. V. R. Horimoto, Kurt K. Lohman, Alisa K. Manning, Tuomo Rankinen, Albert V. Smith, Salman M. Tajuddin, Mary K. Wojczynski, Maris Alver, Mathilde Boissel, Qiuyin Cai, Archie Campbell, Jin Fang Chai, Xu Chen, Jasmin Divers, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E. Harris, Meian He, Fang-Chi Hsu, Anne U. Jackson, Mika Kähönen, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Federica Laguzzi, Jian'an Luan, Nana Matoba, Ilja M. Nolte, Sandosh Padmanabhan, Muhammad Riaz, Rico Rueedi, Antonietta Robino, M. Abdullah Said, Robert A. Scott, Tamar Sofer, Alena Stančáková, Fumihiko Takeuchi, Bamidele O. Tayo, Peter J. van der Most, Tibor V. Varga, Veronique Vitart, Yajuan Wang, Erin B. Ware, Helen R. Warren, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E. Arking, Tin Aung, Eric Boerwinkle, Ingrid Borecki, Ulrich Broeckel, Morris Brown, Marco Brumat, Gregory L. Burke, Mickaël Canouil, Aravinda Chakravarti, Sabanayagam Charumathi, Yii-Der Ida Chen, John M. Connell, Adolfo Correa, Lisa de las Fuentes, Renée de Mutsert, H. Janaka de Silva, Xuan Deng, Jingzhong Ding, Qing Duan, Charles B. Eaton, Georg Ehret, Ruben N. Eppinga, Evangelos Evangelou, Jessica D. Faul, Stephan B. Felix, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Yechiel Friedlander, Ilaria Gandin, He Gao, Mohsen Ghanbari, Bruna Gigante, C. Charles Gu, Dongfeng Gu, Saskia P. Hagenaars, Göran Hallmans, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, Barbara V. Howard, M. Arfan Ikram, InterAct Consortium, Ulrich John, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O. Kilpeläinen, Woon-Puay Koh, José E. Krieger, Stephen B. Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A. Lakka, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Benjamin Lehne, Cora E. Lewis, Yize Li, Shiow Lin, Jianjun Liu, Jingmin Liu, Marie Loh, Tin Louie, Reedik Mägi, Colin A. McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L. Mohlke, Yukihide Momozawa, Mike A. Nalls, Christopher P. Nelson, Nona Sotoodehnia, Jill M. Norris, Jeff R. O'Connell, Nicholette D. Palmer, Thomas Perls, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Neil Poulter, Leslie J. Raffel, Olli T. Raitakari, Kathryn Roll, Lynda M. Rose, Frits R. Rosendaal, Jerome I. Rotter, Carsten O. Schmidt, Pamela J. Schreiner, Nicole Schupf, William R. Scott, Peter S. Sever, Yuan Shi, Stephen Sidney, Mario Sims, Colleen M. Sitlani, Jennifer A. Smith, Harold Snieder, John M. Starr, Konstantin Strauch, Heather M. Stringham, Nicholas Y. Q. Tan, Hua Tang, Kent D. Taylor, Yik Ying Teo, Yih Chung Tham, Stephen T. Turner, André G. Uitterlinden, Peter Vollenweider, Melanie Waldenberger, Lihua Wang, Ya Xing Wang, Wen Bin Wei, Christine Williams, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, John C. Chambers, Ian J. Deary, Tõnu Esko, Martin Farrall, Paul W. Franks, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost Bruno Jonas, Yoichiro Kamatani, Norihiro Kato, Jaspal S. Kooner, Zoltán Kutalik, Markku Laakso, Cathy C. Laurie, Karin Leander, Terho Lehtimäki, Lifelines Cohort Study, Patrik K. E. Magnusson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Ozren Polasek, David J. Porteous, Rainer Rauramaa, Nilesh J. Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E. Wagenknecht, Nicholas J. Wareham, Hugh Watkins, David R. Weir, Ananda R. Wickremasinghe, Tangchun Wu, Wei Zheng, Claude Bouchard, Kaare Christensen, Michele K. Evans, Vilmundur Gudnason, Bernardo L. Horta, Sharon L. R. Kardia, Yongmei Liu, Alexandre C. Pereira, Bruce M. Psaty, Paul M. Ridker, Rob M. van Dam, W. James Gauderman, Xiaofeng Zhu, Dennis O. Mook-Kanamori, Myriam Fornage, Charles N. Rotimi, L. Adrienne Cupples, Tanika N. Kelly, Ervin R. Fox, Caroline Hayward, Cornelia M. van Duijn, E Shyong Tai, Tien Yin Wong, Charles Kooperberg, Walter Palmas, Kenneth Rice, Alanna C. Morrison, Paul Elliott, Mark J. Caulfield, Patricia B. Munroe, Dabeeru C. Rao, Michael A. Province and Daniel Levy
*These authors contributed equally to this work. These authors contributed equally to this work.

PLoS ONE (2018)

Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose

Mickaël Canouil, Beverley Balkau, Ronan Roussel, Philippe Froguel and Ghislain Rocheleau

Frontiers in Genetics (2018)

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling

Angeliki Karamitri*, Bianca Plouffe*, Amélie Bonnefond*, Min Chen, Jonathan Gallion, Jean-Luc Guillaume, Alan Hegron, Mathilde Boissel, Mickaël Canouil, Claudia Langenberg, Nicholas J. Wareham, Christian Le Gouill, Viktoria Lukasheva, Olivier Lichtarge, Philippe Froguel, Michel Bouvier, and Ralf Jockers
*These authors contributed equally to this work. These authors contributed equally to this work.

Science Signaling (2018)

Communications

Oral Presentations

Julia for Intensive Scientific Computing

Mickaël Canouil

National Days of Higher Education and Research Software Developpement - JDEV, Bordeaux, France (2015)

Longitudinal Genetic Modelling: Revisiting Associations of SNPs Associated with Blood Fasting Glucose in Normoglycemic Individuals

Mickaël Canouil, Ghislain Rocheleau, Loïc Yengo and Philippe Froguel

Statistical Methods for Post Genomic Data - SMPGD, Lille, France (2016)

Poster Presentations

Application of Joint Models in Genetic Association Studies

Ghislain Rocheleau, Mickaël Canouil, Loïc Yengo and Philippe Froguel

International Genetic Epidemiology Society - IGES, Baltimore, United-States (2015)

Single Nucleotide Polymorphisms Associated with Fasting Blood Glucose Trajectory and Type 2 Diabetes Incidence: A Joint Modelling Approach

Mickaël Canouil, Philippe Froguel and Ghislain Rocheleau

International Genetic Epidemiology Society - IGES, Toronto, Canada (2016)

Single Nucleotide Polymorphisms Associated with Fasting Blood Glucose Trajectory and Type 2 Diabetes Incidence: A Joint Modelling Approach

Mickaël Canouil, Philippe Froguel and Ghislain Rocheleau

4th Symposium European Genomic Institute for Diabetes (E.g.i.d), Lille, France (2016)

Variants Génétiques Associés à la Trajectoire de la Glycémie à Jeun et à l’Incidence du Diabète de Type 2: Une Approche par Modèle Joint

Mickaël Canouil, Philippe Froguel and Ghislain Rocheleau

Annual Congress of Société Francophone du Diabète (SFD), Lille, France (2017)

Awards

2015

Funding Allocation SFD-Lilly

French speaking Diabetes Society (SFD), Bordeaux, France

“ Detection of New Genomic Variants Associated with Fasting Blood Glucose and Incidence of Type 2 Diabetes Simultaneously ”

http://www.sfdiabete.org

R Packages

snpEnrichment

R package implementing a method for calculating an enrichment statistic of a set of SNP within a GWA signal

Mickaël Canouil and Loïc Yengo (2013)

https://cran.r-project.org/package=snpEnrichment

clere

R package implementing the CLERE methodology

Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil (2014)

https://cran.r-project.org/package=clere